sma4dSema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumourSEMA4D is an oncogene that functions in a variety of tumors, including colorectal carcinoma (14), cervical cancer (15), ovarian cancer (16), soft tissue carcinomas (17), oral cancer (18